USMLE Step 1

USMLE Step 1 QUESTION of the DAY!

Maple Syrup urine disease is due to a defective branched chain alpha-ketoacid dehydrogenase enzyme. A defect in this enzyme causes an inability to metabolize what amino acids?

A) leucine, isoleucine, methionine
B) methionine, valine
C) methionine
D) arginine, lysine, leucine
E) valine, isoleucine, leucine

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Answer: E) valine, isoleucine, leucine. Maple Syrup Urine disease brings a variety of neurological symptoms and a high mortality. It gets its name from the thick, brown urine produced


USMLE Step D.O.C. of the Day!

Drug of choice for

Bacillus Anthracis causing anthrax

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Ciprofloxacin or Tetracycline


USMLE Step 1 Fact of the Day!

Defective enzymes Part I:

Gaucher’s disease: Glucocerebrosidase
Niemann-Pick disease: Sphingomyelinase
Von Gierke’s disease: Glucose-6-phosphatase
Cori’s disease: debranching enzyme